Blood Clots

New Vascular Surgery Chief Stays a Step Ahead

Dr. Kwame Amankwah

Dr. Kwame Amankwah may be new to UConn Health, but he has already made a big impact on the Department of Vascular and Endovascular Surgery.

In his first few months, he performed an aortic dissection repair with a newly approved device that not only covers the tear that caused the dissection but also helps to heal the rest of the aorta and prevent further tears from developing. It was the first procedure with this device at UConn and the second in the state. Amankwah had performed this same procedure in New York, the first of its kind in that state and only the second in the country.

Throughout his career, Amankwah has been among the first to use new technologies for inferior vena cava filters, devices for aortic work, therapies for the removal of clots within the arterial and venous systems, and a device for patients with pulmonary embolisms. The pulmonary embolism device was eventually approved for use in the U.S., and Amankwah was on the data safety review board for the study. He brings all of his experience and expertise to UConn Health. “The goal of all of this is to make UConn a destination center for vascular and endovascular care in the region,” he says.

Amankwah feels the best place to cultivate innovative technology and care is at an academic medical center.

“You get the benefits of interacting with different people, including basic science researchers and clinicians in other departments who are involved in cutting-edge research of their own,” he says. “At an academic medical center, you get a global view of different technologies and different specialties, and you might be able to incorporate some of those things into your own practice.”

Another benefit of working at an academic medical facility, he says, is shaping the future of medicine by working with medical students and residents. Amankwah’s background is steeped in education, and he even writes questions for many national medical exams for medical students and residents.

Looking to the future, Amankwah hopes to offer more new therapies to his patients, specifically new endovascular devices used for thoracoabdominal aneurysms with an upcoming clinical trial that he plans to participate in. “There’s always new technology on the horizon in vascular surgery,” he says. “It’s an exciting time to be practicing medicine.”

3-D Printed Model Allows Brain Surgeons to Rehearse

by Kim Krieger

Dr. Charan K. Singh, right, threads a catheter through a 3-D printed model of arteries in the brain while speaking with Dr. Clifford Yang, one of the  model's creators, at UConn Health.

Dr. Charan K. Singh, right, threads a catheter through a 3-D printed model of arteries in the brain while speaking with Dr. Clifford Yang, one of the model’s creators, at UConn Health. Peter Morenus


The first time a young surgeon threads a wire through a stroke victim’s chest, up through the neck, and fishes a blood clot out of the brain may be one of the most harrowing moments in their career. Now, a UConn Health radiologist and a medical physicist have made it easier for them to get some practice first. The team made a life-size model of the arteries that wire must pass through, using brain scans and a 3-D printer. They will make the pattern freely available to any doctor who requests it.

Five years ago, the Food and Drug Administration (FDA) approved mechanical thrombectomy — using a wire to pull clots out of the brains of stroke victims. A trap at the end of the wire opens like a little snare that captures the clot, which is then dragged out of the patient.

After a couple months of tweaking, a UConn Health radiologist and a medical physicist found they could print a true-to-life teaching model of the brain’s major arteries for about $14.

A lot can go wrong on that journey. One of the most dangerous complications is also one of the most likely: another clot can be accidentally knocked loose from the walls of the arteries and get stuck in the heart, the lungs, or elsewhere in the brain. Computer simulations of the procedure exist, but they are prohibitively expensive for many medical schools to purchase. Yet interventional radiologists and neurosurgeons need to train extensively before they work on a real person.

UConn Health cardiac radiologist Dr. Clifford Yang and medical physicist intern David Brotman knew they could help young doctors feel more comfortable with the mechanics.


Because of the prohibitive costs of computer simulation programs, often the first time a surgeon threads a wire into a stroke victim’s brain to remove a blood clot is during the doctor’s first surgery. Using brain scans and a 3-D printer, a UConn team made a life-size model of the arteries surgeons must navigate during the procedure so they can practice first. The pattern is available for free to any doctor who requests it.


“What matters is the ability of the doctor to be confident in guiding the wire,” says Brotman. He and Yang found a brain scan of a patient with typical blood vessel structure and used the scan to design a 3-D model of the blood vessels. Finding a good scan was easy: UConn has an immense library of scans from computed tomography (CT) and magnetic resonance imaging (MRI) of patients. The tough part was converting the data into something a 3-D printer could interpret. Brotman and Yang found and modified publicly available software to do that, and after a couple months of tweaking, they found they could print a true-to-life teaching model of the brain’s major arteries for about $14.

Technically called a brain perfusion phantom, the model is surprisingly delicate. Holding it in your hand brings home just how small the arteries are, even in an adult man. The top arch of the aorta in the chest, big enough to slide an adult’s pinky finger through, connects to the carotid in the neck and then on to the Circle of Willis in the brain, which is no thicker than a fat piece of yarn. The circle has six branches. Each branch supplies blood to one-sixth of the brain. It is in these branches that clots are most likely to get stuck and cause serious damage.

“We are using this model to teach students,” says UConn interventional radiologist Dr. Charan Singh. “Obviously, it won’t feel like the human body. But it will improve their knowledge of anatomy and give them basic technique on how to move the catheter.”

What matters is the ability of the doctor to be confident in guiding the wire.

Singh demonstrates how a slight twist can violently flip the catheter, which is dangerous. It could knock off new clots into the bloodstream. The model isn’t perfect — there are several different ways a person’s aorta can be shaped, and the other veins can vary too. But students can get good practice with it, Singh says.

Dr. Ketan Bulsara, UConn’s chief of neurosurgery, also likes the technology. He cautions that individual anatomy varies too much for it to be used as the only training tool to learn mechanical thrombectomy, but says that it could potentially be used to visualize other conditions, such as brain tumors. Surgery for brain tumors has significant lead time, and modeling the tumor in advance could personalize and improve patient care.

“Creating these high-level 3-D models customized for individual patients has the potential to significantly improve outcomes and reduce operative times by enhancing surgical planning,” Bulsara says.